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Our in vitro and in vivo
2018-11-06
Our in vitro and in vivo studies show an increase in neurogenesis in the presence of CsA. Our findings are consistent with the idea that CsA is enhancing the survival of DG NPCs and these cells proliferate to give rise to newly born neurons. We cannot rule out the possibility that the DG contains a
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We developed our novel targeting technique in order
2018-11-06
We developed our novel targeting technique in order to overcome one of the major problems with stem cell therapy, namely the high wash-out of injected stem purchase mg115 by the blood and low engraftment rate. This high-washout of over 90% by the blood is irrespectively of the delivery route of the
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Regardless of the detailed mechanisms of metabolic regulatio
2018-11-05
Regardless of the detailed mechanisms of metabolic regulation in ESCs, recent studies indicate that reprogramming MEFs into iPSCs involves dramatic changes in cell metabolism from oxidative phosphorylation to glycolysis (Folmes et al., 2011). Somewhat paradoxically, however, the early phase of the m
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influenza a virus Complicating the impact of relative
2018-11-05
Complicating the impact of relative advantage and disadvantage, however, are numerous studies of the impact of fraternities on college performance and health-related behaviors. In general such studies show that people who join fraternities are more likely to have had a history of drinking before the
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br Discussion Research from diverse global contexts confirms
2018-11-05
Discussion Research from diverse global contexts confirms that children born premaritally experience distinct health and developmental challenges compared to children born to married mothers (Singh, 1998). In sub-Saharan Africa, the consequences of being born premaritally are especially severe, i
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br What is Jedi Public Health in
2018-11-05
What is Jedi Public Health in concept? The metaphor, “Jedi Public Health,” references a scene in the 1977 Star Wars Movie, Episode IV, aptly named for our purposes: “A New Hope.” In that scene, the stormtroopers (the bad guys) stop a car whose passengers include Obi-Wan Kenobi, a Jedi Master, and
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In order to reduce food insecurity a new approach to
2018-11-05
In order to reduce food insecurity, a new approach to private emergency food assistance is needed. Traditional food pantries have become run like businesses, as they have expanded over the past three decades (Saul and Curtis, 2013). However, a business model of efficiency, and the typical outcomes o
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nebivolol hcl To verify the paradox within the longitudinal
2018-11-05
To verify the paradox within the longitudinal data, I estimate a linear probability model that relies on a comprehensive set of individual and contextual controls to study the conditional differences in birth outcomes between immigrants and natives. Formally, I consider the following model:where the
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Introduction The unauthorized use of a famous brand
2018-11-05
Introduction The unauthorized use of a famous brand\'s distinctive elements, such as its brand name, slogan, logo, package design, etc., could negatively impact the brand that is imitated (senior brand), through cognitive, affective, or behavioral effects on its ccr2 antagonist (Loken & John, 2010)
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Gaikwad and Gupta associate acid mine drainage also known as
2018-11-05
Gaikwad and Gupta (2008) associate buspirone hcl mine drainage, also known as abandoned mine drainage, to the reaction of water and oxygen specifically with coal mining. Water passing through the rocks from mining operations that have been deposited on the surface and the underground voids left behi
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In view of these in vitro findings
2018-11-05
In view of these in vitro findings, we tested the association between thrombin generation and complement activation in a second, independent thrombosis/thrombolysis model, and used this model to determine whether C5 is activated by thrombolytic pathways in vivo. Using wild-type mice with stable caro
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The present study quantifies the level of reassurance
2018-11-05
The present study quantifies the level of reassurance a parent may have on diagnostic testing that their child does not have NF1 if there is no sequence variant in NF1 or SPRED1 when their child has 6 or more CAL. Around 25% of children tested did not have an identifiable mutation. Using a Bayesian
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Epigenetic alterations are suggested to regulate gene expres
2018-11-05
Epigenetic alterations are suggested to regulate gene expression without affecting the neuronal metabolism sequence. These modifications include genomic DNA-methylation, histone modifications, chromatin remodeling and miRNA/non-coding RNA-induced regulation of gene expression (Hauptman and Glavac,
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Mechanistically we show that CRL CDT is
2018-11-05
Mechanistically, we show that CRL4CDT2 is the primary target of inactivation by pevonedistat in melanoma and that its toxicity is dependent primarily on the stabilization of the CRL4CDT2 substrates SET8 and p21 both in vitro and in vivo. The lack of a therapeutic response on melanoma cells with hypo
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In addition to the cyclic
2018-11-05
In addition to the cyclic guanosine monophosphate-dependent protein kinase pathway, NO is known to regulate the function of target proteins through S-nitrosylation of cysteine residues (Hess et al., 2005; Jaffrey et al., 2001). One such target is the type 1 ryanodine receptor (RyR1), which is the Ca
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